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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10126/498

タイトル: Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development
著者: Hayashi, Yoshihiro
Toda, Katsumi
Saibara, Toshiji
Okamoto, Sumika
Osanai, Makoto
Enzan, Hideaki
Lee, Gang-Hong
キーワード: fascin
hepatoblast
immunohistochemistry
migration
ultrastructure
雑誌名: Cell and Tissue Research
発行日: 15-Oct-2008
出版者: Springer Berlin / Heidelberg
抄録: Fascin-1 is an actin-bundling protein localized at the core actin bundles within microvillar projections and filopodial extensions in migrating cells. It is expressed at a low level in normal epithelial cells, but at a high level in tumor cells, indicating its importance in the invasion and progression of tumor cells. In addition, fascin-1 is expressed in human and murine embryos, especially at high levels in developing nervous tissues. In this study, we immunohistochemically investigated the expression patterns of fascin-1 during the early stages of rat hepatogenesis. A high expression of fascin-1 was detected in the liver bud and hepatoblasts at embryonic day (ED) 10.5, 11.5 and 12.5. The expression fell by ED13.5 and was not detectable at ED14.5. These observations demonstrated that the expression of fascin-1 is correlated with the migration activity of hepatoblasts during the early stages of liver development in rats.
URI: http://hdl.handle.net/10126/498
出現コレクション:40A 学術論文 Journal Article

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